EDK
Editome Disease Knowledgebase
Gastric Cancer
| Disease name | Gastric Cancer |
|---|---|
| Classfication | Cancer |
| Related Enzyme(s) | |
| EFO | EFO:0000178 |
| DOID | 10541 |
| OMIM | |
| NCI | |
| Definition | NA |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| PODXL | Human | ADAR1;ADAR2 | 1 | A-to-I | RNA misediting is closely associated with GC pathogenesis, the ADAR2-regulated recoding PODXL gene at codon 241 (His to Arg) confers a loss-of-function phenotype that neutralizes the tumorigenic ability of the unedited PODXL. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-miR-200b | ADAR1;ADAR2 | 1 | A-to-I | MI0000342 | miR-200b editing shows correlations with TP53 in breast cancers. High editing level in miR-200b is associated with worse patient survival. |
| Enzyme | Full Name | Location | Ensembl | Targets | Related Diseases | Aliases |
|---|---|---|---|---|---|---|
| AID | Activation-induced cytidine deaminase | Chr12:8602166..8612970 |
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